13.3 Medical Retina – Age-Related Macular Degeneration (AMD)
13.4 Medical Retina - Diabetes
13.5 Medical Retina – Retinal Vein Occlusion (RVO)
13.6 Vitreoretinal Surgery
13.11 Ocular Oncology
For BRVO > 3 months duration, VA 6/12 or worse, no macular haemorrhage:
Macular grid laser = 2x chance of VA gain of 2 lines
Sectoral PRP for NV reduces risk of VH
1984. Argon laser photocoagulation for macular edema in branch vein occlusion. The Branch Vein Occlusion Study Group. Am J Ophthalmol 98(3) 271-282.
Rosenberg, N.R. 1986. Argon Laser Scatter Photocoagulation for Prevention of Neovascularization and Vitreous Hemorrhage in Branch Vein Occlusion: A Randomized Clinical Trial. Archives of ophthalmology (1960) 104(1) 34-41.
Macular laser not beneficial for macular oedema
PRP for NV only once it develops
If ischaemic CRVO - monthly F/U
1995. Evaluation of grid pattern photocoagulation for macular edema in central vein occlusion. The Central Vein Occlusion Study Group M report. Ophthalmology 102(10) 1425-1433.
1995. A randomized clinical trial of early panretinal photocoagulation for ischemic central vein occlusion. The Central Vein Occlusion Study Group N report. Ophthalmology 102(10) 1434-1444.
IVTA no different to macular grid laser for BRVO macular oedema (but 4mg IVTA had greater IOP rise and cataract)
IVTA superior to observation for CRVO (1mg better than 4mg in terms of safety)
Group*, T.S.S.R. 2009. A Randomized Trial Comparing the Efficacy and Safety of Intravitreal Triamcinolone With Standard Care to Treat Vision Loss Associated With Macular Edema Secondary to Branch Retinal Vein Occlusion: The Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study Report 6. Archives of Ophthalmology 127(9) 1115-1128.
Ip, M.S., Scott, I.U., Vanveldhuisen, P.C. et al. 2009. A Randomized Trial Comparing the Efficacy and Safety of Intravitreal Triamcinolone With Observation to Treat Vision Loss Associated With Macular Edema Secondary to Central Retinal Vein Occlusion: The Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study Report 5. Archives of ophthalmology (1960) 127(9) 1101-1114.
Brown, D.M., Campochiaro, P.A., Bhisitkul, R.B. et al. 2011. Sustained Benefits from Ranibizumab for Macular Edema Following Branch Retinal Vein Occlusion: 12-Month Outcomes of a Phase III Study. Ophthalmology 118(8) 1594-1602.
IVR effective (improved 3 lines vs. improved 0 lines sham)
Brown, D.M., Campochiaro, P.A., Singh, R.P. et al. 2010. Ranibizumab for Macular Edema following Central Retinal Vein Occlusion: Six-Month Primary End Point Results of a Phase III Study. Ophthalmology 117(6) 1124-1133.e1121.
Ozurdex effective (reduced vision loss, improved speed and incidence of visual improvement) compared with sham at 6 months
Haller, J.A., Bandello, F., Belfort, R. et al. 2010. Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Macular Edema Due to Retinal Vein Occlusion. Ophthalmology 117(6) 1134-1146.e1133.
Haller, J.A., Bandello, F., Belfort, R. et al. 2011. Dexamethasone Intravitreal Implant in Patients with Macular Edema Related to Branch or Central Retinal Vein Occlusion: Twelve-Month Study Results. Ophthalmology 118(12) 2453-2460.
All rights reserved. No part of this publication which includes all images and diagrams may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the authors, except in the case of brief quotations embodied in critical reviews and certain other noncommercial uses permitted by copyright law.
Vitreoretinal Surgery Online
This open-source textbook provides step-by-step instructions for the full spectrum of vitreoretinal surgical procedures. An international collaboration from over 90 authors worldwide, this text is rich in high quality videos and illustrations.