13 Clinical Trials Summary
13.0 Introduction
13.1 Cornea
13.2 Cataract
13.3 Medical Retina – Age-Related Macular Degeneration (AMD)
13.4 Medical Retina - Diabetes
13.5 Medical Retina – Retinal Vein Occlusion (RVO)
13.6 Vitreoretinal Surgery
13.7 Glaucoma
13.8 Oculoplastics
13.9 Paediatrics
13.10 Neuro-Ophthalmology
13.11 Ocular Oncology
13.6 Vitreoretinal Surgery
PIVOT [lxviii]
Pneumatic Retinopexy vs Vitrectomy for RRD
Superior VA, less metamorphopsia, and reduced morbidity (e.g. less cataract) for pneumatic retinopexy
Primary anatomic success 81% pneumatic retinopexy vs 93% PPV
Hillier, R.J., Felfeli, T., Berger, A.R. et al. 2019. The Pneumatic Retinopexy versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes Randomized Trial (PIVOT). Ophthalmology 126(4) 531-539.
EVS [ix]
Endophthalmitis Vitrectomy Study
If VA LP at presentation endophthalmitis, do better with initial vitrectomy rather than intravitreal antibiotics (3x increased chance of achieving 6/12)
IV antibiotics make no difference
Very old study, may not be applicable today, high rate of endophthalmitis in study, multiple problems with protocol)
See Chapter 13.2 - Cataract
1995. Results of the Endophthalmitis Vitrectomy Study. A randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis. Endophthalmitis Vitrectomy Study Group. Arch Ophthalmol 113(12) 1479-1496.
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Vitreoretinal Surgery Online
This open-source textbook provides step-by-step instructions for the full spectrum of vitreoretinal surgical procedures. An international collaboration from over 90 authors worldwide, this text is rich in high quality videos and illustrations.
