13.11  Ocular Oncology

COMS [cxii,cxiii,cxiv,cxv,cxvi,cxvii]

Collaborative Ocular Melanoma Study

  • Small (1 - 3mm thick, basal diameter < 5mm: 30% grow & mortality 1% 5yrs; Thickness > 2mm, fluid, symptoms, orange pigment, margin within 3mm of optic disc. “TFSOM”
  • Medium (3 - 10mm thick, 5 - 16mm basal diameter): brachytherapy = enucleation, mortality with treatment 20%
  • Large (> 10mm thick, > 16mm basal diameter): pre-enucleation radiation treatment no effect, mortality with treatment 35%

Monosomy 3 = poor prognosis


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